The Cassandra Crossing
A Swedish terrorist group attempts to blow up a US military biological weapons lab in Geneva, but two of them are infected with a deadly, highly contagious pneumonic plague strain called "Cassandra" before they can escape. One is killed, but the other, P.A. Shaddick, boards a transcontinental train bound for Strasbourg. Colonel Stephen Mackenzie, an American military intelligence officer, isolates the entire train, redirecting it to a condemned former quarantine station in Janov, Poland, across the dangerously dilapidated "Cassandra Crossing" bridge, despite protests from the passengers and the World Health Organization (WHO) doctor Elena Stradner. As passengers fall ill and die, Dr. Jonathan Chamberlain, a renowned neurosurgeon on board, works with Elena to find a cure, discovering that oxygen enrichment might help save the uninfected, and that Shaddick, despite his initial infection, is not succumbing to the disease due to a prior tuberculosis vaccination. Mackenzie, fearing a worldwide epidemic if anyone leaves the train, plans to destroy the train on the bridge, killing everyone to contain the virus. Chamberlain and other able-bodied passengers manage to separate the uninfected section of the train before the bomb-rigged front cars are sent over the bridge, which collapses, plunging Mackenzie and the infected into the gorge below. The survivors then continue their journey to freedom, hoping to evade further military pursuit.